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Vardenafil wasn't mutagenic as assessed in both the in vitro bacterial Ames assay or maybe the forward mutation assay in Chinese hamster V79 cells. Vardenafil was not clastogenic as assessed in both the in vitro chromosomal aberration exam or the iIn vivo mouse micronucleus exam.
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Scientific tests in human liver microsomes confirmed that vardenafil is metabolized principally by cytochrome P450 (CYP) isoforms 3A4/five, also to a lesser diploma by CYP2C9.
It can be not possible to ascertain regardless of whether these occasions are linked straight to the usage of PDE5 inhibitors or to other elements [see ADVERSE REACTIONS].
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